A Bump in the Road

I’m not complaining about it but I was taken off my current chemotherapy regiment on Monday. We suspected the Eribulin had stopped working when over the last few weeks a rise in antigens indicated cancer growth. A CT confirmed that the tumors in my liver had enlarged, and a new one popped up my spine. Those in my lungs had shrunk a bit and everything else was kept in check, a mixed bag so to speak.

The past has proven that my cancer likes to take off once unfettered by drugs therefor I was immediately signed up for a new clinical trial. Every trial has its own pretreatment requirements which means I have a whirlwind of appointment over the next ten days. A liver biopsy, labs, echocardiogram, eye exam, and a screening, all with the intention of starting the trial on May 28th.

Happy Memorial Day!

The study itself is called, Phase 1, Two-Part, Multicenter, Open-Label, Multiple Dose, First-IN-Human Study of DS-1062a in Subjects with Advanced Solid Tumors.

Catchy right?

DS-1062a targets a protein called trophoblast cell-surface antigen2 (TROP2) which is found on the surface of the cancer cells in large amounts. DS-1026a an antibody that binds to TROP2 and a drug of topoisomerase I inhibitor, which is called MAAA-1181a. It is thought that the DS-1026a may slow tumor growth by attaching to TROP2 and releasing the drug inside the cells.

Good news is that if it is successful I’ll know rather quickly, and it has shown to work long term (long term relative to the length of the study which started in 2018).

Then there’s the dread pirate side effects

I’m not too worried about them (famous last words?). I’ve been fortunate in that I’ve not had any serious reactions. The big concern is the potential consequences of the two most severe side effects which are mouth sores, and dry eyes. Mouth sores way worse than I experienced with the first study (and those sucked) and eyes dry enough to tear your corneas (that one does worry me). The other side effects are the usual cast of characters, alopecia, fatigue, anemia, vomiting…etc, etc. 

The process is appointment heavy the first few cycles but by cycle three will be one day, every three weeks for a 30 minute infusion. Easy peasy.

I got this.

Comments

  1. You do ‘got this!’ Still, I’m very sorry you have to go through all this, and at the same time very glad they found another trial for you. I wish with all my heart that the treatment will work it’s wonders and the side effects will be so minimal in your case that it will make extra work for the trial people to find out why and note it!

  2. Lisa Shields says

    Oh lord, woman.
    You are sorely missed

    • LOL, Did I die?

      We do seem to have our fair share of trials and tribulations, don’t we? Still, we write when the flow comes. The chemo made writing nearly impossible so I’m hoping this drug regime will ease up on the creative juices a bit.

      Life is for the living, keeping going babe.

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