Another Wicked Good Report: Yawn…

Is this getting boring? OF COURSE NOT!!! Who could get tired of hearing their health is improving? I can’t imagine ever taking my progress for granted. I’m beyond grateful for the people and drugs that are extending my life expectancy.

Two weeks ago I underwent another round of CT’s and a brain MRI…nothing in there of course. Can’t tell you how many times I heard that joke last week.

The CT showed more decreases, and/or stability in the remaining tumors-those are mostly the bone lesions. The decreases mostly soft tissue, like the lungs, and liver.

In other news, my clinical coordinator told me the trial sponsor has decided to forgo the second phase of the study, and jump right to phase three. That is spectacular news. It means patients in the first phase of the study (ME!) are doing so well they are willing to take the financial risk of funding the double blind study.

And guess what? The arm they decided has the best potential for success is the one I am in! FYI: an arm is the combination of drugs being tested. I’m in the phase one study of the drug DGC-0077 which has 6 arms. I am in arm E, taking a combination of palbociclib, fulvestrant, and the GDC-0077.

That is an incredible boost of confidence in the particular drug combination I am taking. It’s especially exciting to my team since I happen to be the only one in this arm at MGH. My team will also be taking part in the phase three trial.

Another milestone, I have reached the 6-month mark which means I get to drop down to one clinic visit a month. I’ll still have testing (CT, MRI) every other month, but no more lab/nurse/doctor visit on day 15.

Other than a few annoying side effects, like my fingernails breaking off at the nail bed…ouch, not much else is going on. My hair still thins about once a month but I don’t seem to be losing all of it. The mouth sores are under control so long as I don’t indulge in things overly acidic, or spicy. My sense of taste comes and goes which can be disheartening but is tolerable.

What’s tolerable is way of life on sooo many levels these days. But I’ll gladly take tolerable for another ten, fifteen years at least.

Happy Valentine’s Day

Love you all.


I’ve Been Holding Out

Last week I had a CT but didn’t get the results until today. However, I’ve been holding out on you. I also visited my eye doctor.

With tears in her eyes she showed us (Jen and I) the scans. No fluid, no cancer. Whoa!

It was hard to not extrapolate that to mean the remaining cancer could have been similarly affected. It was hard to not tell everyone the good news, but I didn’t want to have to temper that a week later with a more sobering report.

NO SUCH PROBLEM!!!

My oncologist’s exact words today were “I couldn’t be any happier with the results.”

According to their metrics, the regression was 1.3% away from being considered a “major” change. This seemed to be slightly unexpected, and very much celebrated by the team.

They will never tell you what outcomes they expect other than generalities and ranges because everyone is different. Nor will they say what more I can surmise from this progress. But, they did confess, it wouldn’t be unrealistic for me to see a continuation of this regression.

I’ll take it.

The crappy stuff, the incredibly awful mouth sores, will be treated with a steroid rinse. It’ll be a while before I can tell if that helps. Of course that cure has its own side effect too-candida. Not great, but a yeast infection in my mouth versus open sores, is a no brainer.

Overall, the last few weeks have been going very well. I’ve had energy and been able to do everything I wanted with minimal side-effect interference.

It was the mouth sore that finally put a damper on my appetite and sense of taste. Only the unpredictable diarrhea is the true buzz kill.

As will always be the case, the end of week two/beginning of week three in the cycle will bring a drop in my WBC, platelets, and energy. Today is day twenty two so my levels should start to go up over the next week.

And so you know I’m not all talk, once I got permission, I got my flu shot.

Next CT is the day before Thanksgiving. I have a lot to be thankful for this year. Besides the obvious pharmaceuticals, it is you all that I’m most grateful for.

You have kept me laughing, cried with me, hugged me, worried about me, made terrible jokes, and spent many hours driving me to and fro.

I love you all.

Lynne

Panic at the Disco

Nothing like causing a panic to bring you down to earth.

I haven’t seen Declan since the day we spent 2 hours (uncomplaining) at the eye doctor, and I was really looking forward to our visit today.

It’s beautiful out. I woke up feeling relatively good despite the lingering pain in my side from radiation. I didn’t need an oxycontin over night or this morning to function (text edit keeps changing oxycontin to oxytocin-please note I know the difference between a hormone and a narcotic). And I have no pain from yesterday’s biopsy.

All is well. Declan arrives all smiles and is delighted by his new batch of dinosaurs, and one Godzilla, my thank you gift. The first thing he says to me is “I’m glad you aren’t dead. I don’t want you to die.”

Me either, little man.

He and I had ordered 1000 pipe cleaners at the beginning of summer. We watch video instructions and follow along but you know I am the one who gets stuck making all the things he wants. This morning I had to improvise as there was no Youtube video instruction for an American flag. We/I managed to replicate one well enough…anything for my Prince Charming.

Then he requested pancakes. Easy peasy. We make, we eat. He runs in and pops the tv on while I start to clean up.

OH DEAR GOD WHAT IS HAPPENING TO ME???

I went dead white. Got light headed, thought my intestines were going to escape my body, while my stomach threatened to abandon ship. I will note, that I did not actually, at any time, get sick. I just felt like I was near death for fifteen minutes. It wasn’t until my face went numb, then my hands went numb, that I started to panic.

When I broke out in a cold sweat and everything went buzzy, I was afraid I’d faint…can I panic now? Not for myself, but I didn’t want to scare Declan. I managed to walk into the family room and tell him I wasn’t feeling well and to watch tv for a bit. I reminded him that Annette is across the street if he needed her. I grab my phone and my hands were shaking so bad I briefly thought that I should go get Annette. Then I texted an SOS to Chris and Kayla. “Come quick, I can’t feel my face,” is not the message you want from the nanny.

Declan is smart and capable. I went back in, laid on the couch and told him I might faint. He said, quite confidently, “That’s okay, I’ll ask Alexa what I need to do for someone who faints.” His instinct to take care of me makes me cry.

So now Chris and Kayla are both on their way. Kayla ratted me out let to Paul know I wasn’t well and he called concerned.

And all I’m thinking is “Fuck. Is this my life now?”

I get a stomach ache and set off a panic at the disco.

I know how annoying it is when I say I’m sorry for a situation not of my own making, but damn it, I’m sorry I’m putting everyone through this. Heck, I’m sorry I’m going through it. It doesn’t mean I don’t appreciate your worry, I do. It’s pure love and I’m grateful for it.

We’re all scared and worried, there is no way to not be. The truth is this is a serious situation, with serious repercussions. The treatments are not fun. Radiation and drugs cause as many problems as they solve. And as hopeful, and as determined as I am to see this though the long-term, the future is unknowable.

It’s the unpredictableness of it all that is most challenging. We have no idea which side effects will strike me, how severely or mildly, or how short or long lasting they’ll be.

It truly is a life that can only be lived one day a time.

However, I believe in making plans for the future, because they help one see past the current situation. Giving yourself things to look forward to, and to live for, can make a big difference in how you weather the storms chronic illness throws at you.

Lillian will be home Sunday, Tracey moves into her new house Aug 3rd, Kayla’s bridal shower is the 4th, her and Chris’s wedding is Sept 1st, Oct 3rd I’m hosting Sara’s baby shower, Oct 16th is our 26th wedding anniversary, I’m redecorating Eva’s and Lillian’s bedrooms (I seem to have a lot more company now).

I have a lot to look forward to.

I Feel Love, Donna Summer

Five and Done

It has been duly noted that not being updated is making some of you anxious. If you are ever in need of reassurance or just need to hear my lovely voice, for crying out loud, call me. You are not bothering me. I assure you, if I don’t want to talk I will not answer the phone.

After a lovely weekend with Sara and the Indoe family, I had a nice quiet Monday, with my 4th dose of radiation, and concluded that treatment with the 5th dose today. 

I was doing great until yesterday afternoon when I suddenly felt like I’d gone a few rounds with Muhammed Ali pounding the crap out of my left side.

The radiation, like many cancer treatments, tends to make one worse before it makes you better. And I was feeling much worse for wear when I woke this morning.

I popped an eight-hundred mils of ibuprofen, and a few hours later off I went to my last app’t. While I was there I asked to see the doctor since I was becoming apprehensive about my biopsy scheduled for Wednesday (we have to be in Boston at 6:30am) after being in considerable pain this morning, I feared tomorrow would be unbearable. 

Oxycontin to the rescue. I’m guessing that will be a recurring theme. 

Tomorrow being biopsy day means Paul and I will spend a lovely morning together. We do so enjoy this alone time. At least it is early enough to avoid rush hour traffic. 

Then at long last I have Declan Thursday! I haven’t seen him since the morning he spent with me at the ophthalmologist…geez, was that really only 4 weeks ago?…and I can’t imagine what he is thinking happened to me. 

I am well supplied with a new group of Dinos for the Dino Compound we started out back, and his new crafting medium, pipe cleaners. Which really means him saying “I’m going to make a turtle,” and then handing me everything. 

I’ll update you after my app’t with Dr Juric on Friday.  I should be starting the meds and learn more about the clinical trial, though I don’t think my participation can be determined until the biopsy results are in. 

Radiation Station

I met Dr. Jim McIntrye on Tuesday. He’s my new radiologist. Luckily for me I don’t have to go to Boston for my treatments since they have a lovely cancer center over in Danvers.

Jim is a chatty fellow. I learned more about his family in one meeting than I’ve ever learned about doctors I’ve know for decades. He’s also a hugger. Which is okay with me, huggers live longer and that is our goal.

Today I had my first dose. One down, four to go. Annoyingly they are at one o’clock in the afternoon. Cancer is very inconvenient.

A lovely young women reached out to me (I signed up to be notified of pertinent clinical trials) to participate in a fatigue study of patients taking Ibrance. It’s a seven week study that takes place over seven months that consists of questionnaires, wearing a special sleep watch and a Fitbit. Easy peasy, and they pay you small stipend, and I get to keep the Fitbit. This cancer thing is really paying off!

Dr Juric called to tell me they decided to biopsy the lymph node under my collar bone. Soft tissue is a much better material to type than bone. It shows up well on the PET scan even though they can’t feel it. Waiting for that app’t to get settled. And he said the insurance company had approved my taking Ibrance. I’ll see him end of next week and finally get going on the drugs. Woohoo!

I’ve had a migraine off and on for three days now. It seems related to the lesion on T8 causing me pain, the one they are radiating. It can take weeks for the full effects of radiation to take effect. Let’s hope I don’t put an ice pick through my temple before then.

I started driving again since the fluid has decreased a bit in my right eye. The distortion isn’t making me queasy anymore. I’m not sure I want to drive to Boston myself yet but the local roads I can drive in my sleep were no problem. I assure you my vision is clear and I’m not endangering myself or anyone else, it was merely a motion sickness issue.

Thank you all for messages of support and love. It means more to me than I could possible express. Huh, you shut me up. Keep up the good work.